Alex Pym joined K-RITH (the KwaZulu-Natal Research Institute for Tuberculosis and HIV) – now part of Africa Health Research Institute (AHRI) as an Associate Investigator in November 2011, and is an Associate Professor at the Nelson Mandela School of Medicine, University of KwaZulu-Natal and University College London. He was trained in Clinical Medicine, Infectious Diseases, Microbiology, and Mycobacterial Genetics. He completed his PhD in the laboratory of Professor Stewart Cole at the Institute Pasteur in Paris, followed by post-doctoral studies with Peter Small at Stanford University. He has a broad research experience in TB, and has published on Esx secretion systems, recombinant TB vaccines, and population genetics of Mycobacterium tuberculosis. Before joining AHRI he worked at the MRC in South Africa on clinical drug development including the evaluation of bedaquiline in MDR-TB patients. Now established at the AHRI, his laboratory is focussed on understanding the biological basis of resistance and persistence in M. tuberculosis and identifying biomarkers of treatment response, key requirements for improving treatments for tuberculosis. His laboratory takes a multi-disciplinary approach to these problems, including functional genomics, transcriptomics, animal models and innovative bacterial single cell techniques.