Tivani Mashamba-Thompson is the Academic Leader for Research in the School of Nursing and Public Health, University of KwaZulu-Natal (UKZN), a NRF rated Scientist and Health Professions Council of South Africa (HPCSA) registered Medical Biological Scientist. She is a member of number of leadership boards within the College of Health Sciences, UKZN. Her research interest is translational medicine, with a focus on the implementation research for HIV, STD and TB (HAST) point-of-care (POC) diagnostics in resource-limited settings. POC diagnostics are defined as pathology tests performed in a clinical setting (such as family medicine or primary healthcare clinics) at the time of patient consultation, generating a test result that is used to make an immediate informed clinical decision that contributes to an improved health outcome for the patient. Mashamba-Thompson’s research on POC diagnostics is aimed at translating findings in fundamental research into medical practice and meaningful health outcomes. To date, diagnostics receive much less research attention than vaccines and drugs. The advent of POC diagnostics in rural and resource-limited settings provides a promising hope for improving health outcomes, particularly in HIV-epidemic countries. Despite recent investments in global health diagnostics, the potential for POC diagnostics to generate value for patients and health systems has not been met across all settings, particularly in low-and middle-income countries where disease burdens are high, and diagnosis remains a big gap in care cascades.