David Lewinsohn is a Professor of Pulmonary and Critical Care Medicine at Oregon Health and Science University. He also has adjunct appointments in Molecular Microbiology and Immunology as well as the Vaccine and Gene Therapy Institute. Lewinsohn is interested in the mechanisms by which the human immune system can recognise cells infected with Mycobacterium tuberculosis, the causative agent of tuberculosis (TB). TB remains a leading cause of infectious disease mortality, and a disease whose impact is amplified by infection with HIV. While most who get infected with Mtb remain healthy, some go on to develop disease. Understanding how the immune system recognises infection with Mtb is likely critical to developing improved vaccines and diagnostics. The Lewinsohn Laboratory has used detailed analysis of human, CD8 clones to define the underlying mechanisms of how the host might recognise the infected cell, and then used these insights to evaluate the immune response in those who have TB, and in those who appear resistant.