Characterisation of regulatory B cells and their impact on cytotoxic T lymphocyte responses in untreated and early antiretroviral treated acutely infected HIV patients

Characterisation of regulatory B cells and their impact on cytotoxic T lymphocyte responses in untreated and early antiretroviral treated acutely infected HIV patients

Associated Students: 
Project Level: 
Email Address: 
daniel.muema@ahri.org
Phone Number: 
+27 71 993 8217

Having previously described the defects of B cells in HIV-infected children, Muema is investigating the causes and consequences of B-cell defects. HIV has been suggested to exert breaks on the immune system as an escape mechanism, sometimes by causing the expansion of modulatory cells that dampen the quality of immune responses. He is currently investigating if HIV hijacks B cells, the immune cells that produce antibodies against the virus, by programming them to instead dampen the effect of other components of the immune system that could be otherwise effective in controlling the infection. This will inform interventions that could augment the useful immune responses against the virus.