HIV and TB are endemic in South Africa. Of all the challenges associated with HIV, TB poses as the largest obstacle. It is recorded as one of the main causes of death amidst HIV positive individuals. Comorbidity of HIV and TB act not only as a risk to patients seeking treatment, but to the healthcare workforce in a setting where resources are limited. The prevention, treatment and management of comorbid diseases is seen to be one of the most significant challenges faced by modern medicine and healthcare systems. A healthcare system of a country is negatively affected by the prevalence of comorbidity, as it is associated with increased mortality rates, poor quality of life and a heightened demand on the use of healthcare and healthcare resources. South Africa poses as a uniquely diverse population and such diversity has the ability to compound social determinants of health impacting the population. Previous research has identified the biological qualitative aspects of comorbidity amidst the HIV and TB population in South Africa. However a limited amount of research has explored the qualitative lived experiences of patient’s living with chronic comorbid HIV and TB. Furthermore, little attention has been given to the psychosocial elements. Kourie’s study aims to explore the lived experiences of patients who possess chronic comorbid HIV and TB in an urban setting in South Africa. Qualitative methods such as ethnographic observations, semi-structured interviews with; community advisory bodies and healthcare workers, and patient focus groups will be used. Purposive sampling will be adopted. Data analysis will include a thematic content analysis and data will be triangulated. The results of this study may have implications for potential further research relating to larger studies on frameworks of care provision, and determinants of health; practice based on needs of patients obtaining care for multiple conditions; policy related to how care is implemented for people living with co-morbidity and theory related to ways in which we understand the lived experience of co-morbidity.