Home Researchers/Supervisors Daniel Muema

Researchers/Supervisors

Daniel Muema

SANTHE Scientific Innovation Awardee,
SANTHE Supervisor


Kenya AIDS Vaccine Initiative (KAVI), University of Nairobi, Nairobi, Kenya

Project

Signature of long-lived HIV-specific memory B-cell lineages

Collaboration Interests
  • Assessment of antibody responses to candidate vaccines across all infectious diseases

Daniel Muli Muema completed his PhD training at the Open University UK in collaboration with the University of Liverpool and the Kenya Medical Research Institute (KEMRI)–Wellcome Trust Research Programme.

During his PhD, he described defects in B-cell responses in HIV-infected children. He later undertook postdoctoral training at the Africa Health Research Institute (AHRI), where he investigated the causes and consequences of B-cell dysfunction in people living with HIV.

He subsequently returned to Kenya to establish a research group at the Kenya AIDS Vaccine Initiative (KAVI) Institute of Clinical Research at the University of Nairobi. His current work focuses on understanding B-cell immune responses that can be induced by vaccines to protect against HIV infection.

His research interests are driven by a commitment to generating new knowledge and contributing to solutions for major public health challenges, particularly HIV in sub-Saharan Africa.

Publications
Integrated single-cell analysis of multicellular immune dynamics during hyperacute HIV-1 infection Association between the cytokine storm, immune cell dynamics, and viral replicative capacity in hyperacute HIV infection Contrasting Inflammatory Signatures in Peripheral Blood and Bronchoalveolar Cells Reveal Compartment-Specific Effects of HIV Infection HIV status alters disease severity and immune cell responses in Beta variant SARS-CoV-2 infection wave Similar Antibody Responses Against Severe Acute Respiratory Syndrome Coronavirus 2 in Individuals Living Without and With Human Immunodeficiency Virus on Antiretroviral Therapy During the First South African Infection Wave Coordinated Fc-effector and neutralization functions in HIV-infected children define a window of opportunity for HIV vaccination Low Immune Activation in Early Pregnancy Is Associated With Preterm But Not Small-for-gestational-age Delivery in Women Infected With Human Immunodeficiency Virus Initiating Antiretroviral Therapy in Pregnancy: A Prematurity Immunology in HIV-infected Mothers and their Infants Study (PIMS) Case-control Study in Cape Town, South Africa

SANTHE is an Africa Health Research Institute (AHRI) flagship programme funded by the Science for Africa Foundation through the DELTAS Africa programme; the Gates Foundation; Gilead Sciences Inc.; and the Ragon Institute of Mass General, MIT, and Harvard.

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