Projects

This study will identify a group of individuals from Harare Public Health facilities in Zimbabwe that have been diagnosed with COVID-19 and follow them up to four months to determine long COVID-19 status. Participants will be recruited from patients receiving…

Wadzanai Majeese’s research is focused on generating three dimensional (3D) spheroids (alginate microspheres) incorporating virulent Mycobacterium tuberculosis (Mtb) H37Rv and peripheral blood mononuclear cells (PBMCs). The microspheres form a granuloma similar to occurrence in human infection. Mtb is allowed to…

This study will identify a group of individuals from Harare Public Health facilities in Zimbabwe that have been diagnosed with COVID-19 and follow them up to four months to determine long COVID-19 status. Participants will be recruited from patients receiving…

A high rate of HIV and tuberculosis (TB) disease burdens continue to plague Sub-Saharan Africa. HIV, which infects CD4+ T cells of the immune system can result in greater vulnerability to additional infections such as TB or hepatitis virus for…

Severe Acute Respiratory Syndrome 2 (SARS-CoV-2) is a virus with fatal health outcomes and its associated disease, Corona Virus 2019 (COVID-19), has claimed many lives worldwide. Viruses are subject to evolutionary pressures and often mutate at the epitopes to cause…

Fellowship 28 February 2023

Characterisation of HIV-1 Env in virus reservoirs found in lymph nodes and peripheral blood

Despite the fact that antiretroviral therapy (ART) has significantly increased the lifespan of HIV-infected people and improved their quality of living, it is not curative due to the presence of a latent reservoir. Latency is described as the incorporation of…

The HIV pandemic is caused by viruses of type 1 group M (HIV-M). Beside the majority of these viruses, there are many genetically divergent variants, leading to the definition of HIV-2 and groups N, O, and P in HIV-1. HIV-1…

A recent development in vaccines, such as the HIV eOD-GT8 vaccine, indicate that the human immune germline could be targeted. Such vaccines work by priming the naive B cell repertoire to generate protective broadly neutralising antibodies. Success of these germline…

Human macrophages are a cell type preferentially infected by Mycobacterium tuberculosis (Mtb), the biological agent which causes tuberculosis disease (TB), but can also be infected by HIV. Both Mtb and HIV induce host-immune responses to infection whose effectors are genes…

Manyeruke’s study seeks to determine the progression in lung functions following COVID-19 infection and to further understand the impact of comorbid conditions like HIV and tuberculosis on the trajectory of lung function in patients diagnosed with COVID-19. His project will…