Grace Muzanyi

Grace Muzanyi is a Principal Investigator at the Makerere University in Kampala, Uganda, Biomedical Science Research Centre (MAKBRC). He also serves as a Senior Clinical Trials Coordinator at the Uganda–Case Western Reserve University Research Collaboration (UCRC) and works as a clinical trial consultant.

His research focuses on tuberculosis (TB) immunology, particularly the relationship between immune biomarkers and TB disease progression and treatment response. He studies cytokines including IL-2, IL-1Ra, IP-10, MIP-β and MCP-1, and their association with sputum culture outcomes, including time to positivity in liquid culture and colony counts in solid media.

His work evaluates how baseline and longitudinal cytokine profiles correlate with clinical response, disease severity and radiographic extent of TB, as well as differences between active TB, latent TB and TB-exposed individuals, stratified by HIV status. He also investigates cytokine dynamics during TB treatment in both active and latent disease states.

In addition, he assesses the cost-effectiveness of novel point-of-care immunological tests for TB compared with standard sputum culture methods, with the goal of improving TB diagnosis and treatment monitoring.