Home Researchers/Supervisors Ernest Oduro-Kwateng

Researchers/Supervisors

Ernest Oduro-Kwateng

SANTHE Scientific Innovation Awardee


HIV Pathogenesis Programme (HPP)/University of KwaZulu-Natal (UKZN), Durban, South Africa

Collaboration Interests
  • Antiviral natural products
  • Bioinformatics
  • Modelling
  • Natural product–based therapeutics

Ernest Oduro-Kwateng is a PhD student at the HIV Pathogenesis Programme (HPP), University of KwaZulu-Natal, Durban, South Africa. His research focuses on computational bioinformatics, natural product-based therapeutics and the molecular mechanisms of HIV pathogenesis.

He integrates systems pharmacology, molecular modelling and experimental approaches to study host–pathogen interactions and support the development of HIV cure-oriented interventions. His interests include computational drug discovery, HIV latency, immunomodulation, antiviral natural products and nano delivery systems. He has contributed to several peer-reviewed publications in these areas. He is committed to advancing affordable, locally relevant therapeutics and vaccines for sub-Saharan Africa through African-led innovation in infectious diseases.

Publications
Phytochemicals from Euclea natalensis Modulate Th17 Differentiation, HIV Latency, and Comorbid Pathways: A Systems Pharmacology and Thermodynamic Profiling Approach De Novo Rational design of peptide-based covalent inhibitors via mapping of complementary binding site residues – technical protocol and case study on KRASG12C and BTK481C A Computational Approach for Designing a Peptide-Based Acetyl-CoA Synthetase 2 Inhibitor: A New Horizon for Anticancer Development Nanohydrogel of Curcumin/Berberine Co-Crystals Induces Apoptosis via Dual Covalent/Noncovalent Inhibition of Caspases in Endometrial Cancer Cell Lines: The Synergy Between Pharmacokinetics and Pharmacodynamics Alternaria alternata (Fr) Keissl Crude Extract Inhibits HIV Subtypes and Integrase Drug-Resistant Strains at Different Stages of HIV Replication De Novo Rational Design of Peptide-Based Protein–Protein Inhibitors (Pep-PPIs) Approach by Mapping the Interaction Motifs of the PP Interface and Physicochemical Filtration: A Case on p25-Cdk5-Mediated Neurodegenerative Diseases Unveiling therapeutic frontiers: DON/DRP-104 as innovative Plasma kallikrein inhibitors against carcinoma-associated hereditary angioedema shocks - a comprehensive molecular dynamics exploration Allosteric covalent inhibition of TOE1 as potential unexplored anti-cancer target: structure-based virtual screening and covalent molecular dynamics analysis The Juxtaposition of Allosteric and Catalytic Inhibition in PLK1: Tradeoff for Chemotherapy and Thermodynamic Profiles of KBJK557 and BI 6727 DON/DRP-104 as potent serine protease inhibitors implicated in SARS-CoV-2 infection: Comparative binding modes with human TMPRSS2 and novel therapeutic approach

SANTHE is an Africa Health Research Institute (AHRI) flagship programme funded by the Science for Africa Foundation through the DELTAS Africa programme; the Gates Foundation; Gilead Sciences Inc.; and the Ragon Institute of Mass General, MIT, and Harvard.

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