Publications

Human lung-resident mucosal-associated invariant T cells are abundant, express antimicrobial proteins, and are cytokine responsive

Communications Biology

Number of Volumes: Volume 5, Article number: 942 (2022)

Number of Citations: 2

The human lungs are a crucial part of our respiratory system, responsible for taking in oxygen and expelling carbon dioxide. Inside the lungs, there are specialized immune cells known as mucosal-associated invariant T cells (MAIT cells) that play a crucial role in defending the lungs against infections. A recent study investigated these MAIT cells in the human lungs to understand their abundance, functions, and responsiveness to cytokines (molecules that regulate immune responses).

The researchers found that MAIT cells are abundant within the human lungs, indicating their importance in protecting this vital organ from harmful pathogens. Moreover, they discovered that MAIT cells are equipped with antimicrobial proteins, which are substances that can directly target and destroy harmful microorganisms like bacteria and viruses. This suggests that MAIT cells have a powerful ability to fight off infections and maintain lung health.

Additionally, the study revealed that MAIT cells are responsive to cytokines, meaning they can quickly react and adapt to changes in the lung environment caused by infections or inflammation. This responsiveness allows them to mount effective immune responses and assist in the clearance of invading pathogens.

Overall, the findings from this research shed light on the critical role of MAIT cells in the human lungs. Understanding the abundance, antimicrobial functions, and cytokine responsiveness of these specialized immune cells can help researchers develop better strategies to protect and treat lung infections, ultimately contributing to improved lung health and overall well-being.

SANTHE is an Africa Health Research Institute (AHRI) flagship programme funded by the Science for Africa Foundation through the DELTAS Africa programme; the Bill & Melinda Gates Foundation; Gilead Sciences Inc.; and the Ragon Institute of Mass General, MIT, and Harvard.