Modeling the impact of different PrEP targeting strategies combined with a clinic-based HIV-1 nucleic acid testing intervention in Kenya


This research paper focuses on understanding how different strategies for preventing HIV transmission and diagnosing individuals sooner after they have been infected can help reduce HIV transmission in Kenya. Pre-exposure prophylaxis (PrEP) is a preventive approach where medication is taken to reduce the risk of getting infected with HIV. The researchers considered various scenarios for distributing PrEP, targeting different groups of people who are at higher risk of contracting HIV. They also looked at the effect of combining PrEP strategies with HIV testing using advanced methods that can detect the virus even in its early stages. Providing PrEP to both individuals with more than one partner at the same time and to uninfected partners of recently diagnosed patients reduced new HIV infections and was efficient based on numbers needed to treat to prevent one HIV infection. These findings offer guidance on how to allocate resources and design effective strategies to combat HIV transmission. By using computer models, researchers can predict the potential outcomes of different approaches without conducting real-world experiments. However, it’s important to remember that these are computer-generated predictions and need to be validated through real-world studies.

SANTHE is an Africa Health Research Institute (AHRI) flagship programme funded by the Science for Africa Foundation through the DELTAS Africa programme; the Bill & Melinda Gates Foundation; Gilead Sciences Inc.; and the Ragon Institute of Mass General, MIT, and Harvard.