Myeloid cell expression of CD200R is modulated in active TB disease and regulates Mycobacterium tuberculosis infection in a biomimetic model

Front Immunol

The article explores how the expression of CD200R, a receptor on myeloid cells, is influenced during active tuberculosis (TB) and how it impacts the infection by Mycobacterium tuberculosis (Mtb). The researchers found that in individuals with active TB, the levels of CD200R on myeloid cells are altered. Using a biomimetic model, which mimics human tissue and immune responses, they demonstrated that CD200R plays a role in controlling Mtb infection. Modulating CD200R expression could, therefore, be a potential therapeutic strategy to manage TB infection.

SANTHE is an Africa Health Research Institute (AHRI) flagship programme funded by the Science for Africa Foundation through the DELTAS Africa programme; the Bill & Melinda Gates Foundation; Gilead Sciences Inc.; and the Ragon Institute of Mass General, MIT, and Harvard.