Researchers/Supervisors

Aubin Nanfack

SANTHE Scientific Innovation Awardee


Centre International De Référence “Chantal Biya” for Research on HIV/AIDS (CIRCB), Yaoundé, Cameroon

Project

Metabolomic biomarkers of HIV reservoir size and reactivation potential in people living with HIV on antiretroviral therapy

Humoral immune response to non-B HIV-1 infection in children in Cameroon

Collaboration Interests
  • HIV diversity
  • HIV drug resistance mutations
  • HIV neutralising antibodies
  • HIV super-infection and HIV co-infections (HBV/HCV)
  • HIV viral reservoirs

Aubin Nanfack is the Head of the Laboratory of Immunology and Microbiology at the Centre International de Référence “Chantal Biya” for Research on HIV/AIDS (CIRCB) in Cameroon. He has extensive training and experience in biochemistry, immunology, and molecular biology, with a strong focus on HIV research. His expertise includes HIV-1 genetic diversity, co-infections (HIV/HBV and HIV/HCV), drug resistance mutations, viral reservoirs, superinfection, and neutralising antibody responses.

His research group focuses on characterising HIV-1 reservoirs and neutralising antibodies in individuals infected with HIV-1 CRF02_AG, the most prevalent subtype in Cameroon and one of the most widely distributed globally. He investigates how viral persistence is maintained despite effective antiretroviral therapy and how this knowledge can inform curative strategies.

His work contributes to efforts aimed at developing safe, affordable HIV cure approaches and effective vaccines capable of inducing functional antibody responses, including broadly neutralising antibodies. A key goal of his research is to better understand the viral reservoir environment and antibody-mediated immunity to support the design of interventions that could ultimately help end the HIV epidemic.

SANTHE is an Africa Health Research Institute (AHRI) flagship programme funded by the Science for Africa Foundation through the DELTAS Africa programme; the Gates Foundation; Gilead Sciences Inc.; and the Ragon Institute of Mass General, MIT, and Harvard.