Home Researchers/Supervisors Robert Krause

Researchers/Supervisors

Robert Krause

SANTHE Path-to-Independence Awardee


Africa Health Research Institute (AHRI),
Durban, South Africa

Project

B cell tissue residence in the human TB lung and their impact on the TH1 or TH2 response

Collaboration Interests
  • Antibodies
  • B cell immunology
  • TB Immunology
  • Tertiary lymphoid follicles

Robert Krause is a Research Associate in the Leslie Laboratory at the Africa Health Research Institute (AHRI), Durban, South Africa. His research interests span communicable diseases, with a background in malaria diagnostics during his PhD. He has also contributed to multiple SARS-CoV-2 studies during the COVID-19 pandemic before transitioning his focus to tuberculosis (TB).

His current work investigates B cell immunology in TB, particularly within the human TB lung. He studies immune cell aggregates containing B cells located near tuberculous lesions, aiming to understand whether these structures contribute to controlling TB infection or whether they may instead support disease progression.

Publications
Infection pre-Ad26.COV2.S-vaccination primes greater class switching and reduced CXCR5 expression by SARS-CoV-2-specific memory B cells Failure to decrease HbA1c levels following TB treatment is associated with elevated Th1/Th17 CD4+ responses EGF-dependent re-routing of vesicular recycling switches spontaneous phosphorylation suppression to EGFR signaling Mycobacterium tuberculosis senses host Interferon-γ via the membrane protein MmpL10 HIV status alters disease severity and immune cell responses in Beta variant SARS-CoV-2 infection wave

SANTHE is a pan-African consortium, with the Africa Health Research Institute (AHRI) serving as the operational site lead and funded by the Science for Africa Foundation through the DELTAS Africa programme; the Gates Foundation; Gilead Sciences Inc.; Aidsfonds; and the Ragon Institute of Mass General, MIT, and Harvard.

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