Home Researchers/Supervisors Kavidha Reddy

Researchers/Supervisors

Kavidha Reddy

SANTHE Researcher & Data Science Support Awardee,
SANTHE Supervisor


Africa Health Research Institute (AHRI), Durban, South Africa

Collaboration Interests
  • HIV clinical studies
  • HIV-1 reservoirs
  • HIV-1 subtype C infection
  • Virology

Kavidha Reddy is a Research Associate at the Africa Health Research Institute (AHRI) in Durban, South Africa. Her research focuses on the longitudinal characterisation of the HIV-1 subtype C reservoir, a key barrier to HIV cure strategies.

Her work addresses the limited understanding of HIV reservoir dynamics in African populations, particularly for subtype C, the most prevalent HIV-1 subtype globally and dominant in southern Africa. She investigates variability in the size, composition and genetic landscape of persistent reservoir genomes. Her research contributes to the development of therapeutic and cure strategies, as well as vaccine design, aimed at addressing long-term HIV persistence.

Publications
Functional characterization of Vif proteins from HIV-1 infected patients with different APOBEC3G haplotypes APOBEC3G expression is dysregulated in primary HIV-1 infection and polymorphic variants influence CD4+ T-cell counts and plasma viral load HIV-1 DNA sequence diversity and evolution during acute subtype C infection Clonal expansion of genome-intact HIV-1 in functionally polarized Th1 CD4+ T cells Irreversible depletion of intestinal CD4+ T cells is associated with T cell activation during chronic HIV infection Limited Sequence Variation and Similar Phenotypic Characteristics of HIV-1 Subtype C Gag Variants Derived From the Reservoir and Pre-Therapy Plasma

SANTHE is an Africa Health Research Institute (AHRI) flagship programme funded by the Science for Africa Foundation through the DELTAS Africa programme; the Gates Foundation; Gilead Sciences Inc.; and the Ragon Institute of Mass General, MIT, and Harvard.

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