Low pre-existing endemic human coronavirus (HCoV-NL63)-specific T cell frequencies are associated with impaired SARS-CoV-2-specific T cell responses in people living with HIV

Front Immunol

This article investigates the relationship between pre-existing immune responses to a common human coronavirus (HCoV-NL63) and the ability to mount effective T cell responses against SARS-CoV-2 in individuals living with HIV. The study suggests that lower frequencies of pre-existing HCoV-NL63-specific T cells are associated with weakened T cell responses to SARS-CoV-2 in people with HIV. This highlights the potential impact of prior immune history on the ability to combat new infections, specifically the novel coronavirus. Understanding these associations could contribute to improving strategies for managing and enhancing immune responses, especially in populations with HIV.

Disclaimer: This lay summary was generated by AI and has not been approved by any of the authors yet.

SANTHE is an Africa Health Research Institute (AHRI) flagship programme funded by the Science for Africa Foundation through the DELTAS Africa programme; the Bill & Melinda Gates Foundation; Gilead Sciences Inc.; and the Ragon Institute of Mass General, MIT, and Harvard.