Recommendations from the 2nd Consensus Workshop on Analytical Treatment Interruption in HIV Research Trials

This publication shares updated guidance from a group of international experts on how to safely conduct research studies that involve planned pauses in HIV treatment. These pauses are used in research to better understand how the virus behaves and to test new approaches aimed at long-term control or cure. 

The experts reviewed current evidence and experiences from past studies to develop clear recommendations. They emphasized that stopping treatment in a research setting can carry risks, including the return of the virus and potential health effects for participants. Because of this, they stress the importance of careful planning, close monitoring, and strong ethical standards. 

Key recommendations include selecting participants carefully, ensuring they fully understand the risks, and providing frequent health checks during and after the treatment pause. The group also highlights the need for clear rules on when to restart treatment to protect participants’ health. In addition, they encourage researchers to involve communities in the design of studies and to communicate openly about risks and benefits. 

Overall, the publication aims to make future HIV research safer and more consistent across studies. By following these guidelines, researchers can better protect participants while advancing efforts to find long-term solutions for HIV.