Denis Kyabaggu


Uganda CWRU Research Collaboration (UCRC) Kampala, Uganda


Influence of SP110 polymorphisms in human macrophages of pulmonary tuberculosis disease among Ugandans

Collaboration Interests
  • Gene editing (CRISPA CAS9 techniques and confocal microscopy for tissue culture reading)
  • GWAS studies (TB and HIV infected populations)
  • Primary human macrophages derived from PBMCs
  • Small animal models (macrophage work)

Denis Kyabaggu is a PhD student at Makerere University in the Department of Immunology and Molecular Biology in Kampala, Uganda. He studied his undergraduate degree in Biomedical Laboratory Technology, and an MSc Molecular Biology at Makerere University before joining Boston University, Boston, USA for an MSc in Pathology Laboratory Sciences. Kyabaggu is passionate about biomedical research in infectious diseases, particularly HIV, tuberculosis (TB) and viral hemorrhagic fevers. Presently, he is studying the mechanisms of establishment of Mycobacterium tuberculosis (Mtb) infection in human cells called macrophages, more so in the context of co-infections such as HIV. This work is relevant for understanding biological effectors of protective host immunity against Mtb at the cellular level. Results of this study may also inform the subsequent design of improved preventive and therapeutic strategies capable of eliminating pathogen reservoirs from host macrophages. This knowledge gap is a key element in the control and eventual global elimination of TB disease and its co-morbidities, particularly HIV. As part of this work, Kyabaggu is passionate about gaining skills in whole genome sequencing and large dataset analysis as well as community engagement to communicate scientific findings.

SANTHE is an Africa Health Research Institute (AHRI) flagship programme funded by the Science for Africa Foundation through the DELTAS Africa programme; the Bill & Melinda Gates Foundation; Gilead Sciences Inc.; and the Ragon Institute of Mass General, MIT, and Harvard.