Fellows

Mahlatse Maseeme

ACP-HIV/TB Fellowship Recipient


Africa Health Research Institute (AHRI), Durban, South Africa

Project

Characterising immune signatures in recent asymptomatic Mycobacteria (Mtb) infection to reveal correlates of protection in Mtb infection and TB disease

Collaboration Interests
  • Community and public engagement
  • HIV transmission
  • Social sciences
Supervisor

Mahlatse Maseeme began his academic training at the University of the Witwatersrand in Johannesburg, South Africa, where he completed both a Bachelor of Science (BSc) and a Bachelor of Health Sciences Honours (BHSc) in 2016. He later joined the Africa Health Research Institute (AHRI) in 2021 for his master’s degree, which he completed cum laude, focusing on immunometabolism in tuberculosis (TB) and HIV.

His master’s research explored how metabolic processes influence immune cell function during TB and TB–HIV co-infection, with the aim of identifying biomarkers for disease diagnosis and treatment response.

For his PhD, he is investigating immune correlates of protection against Mycobacterium tuberculosis (Mtb). His work is based on the observation that many individuals are exposed to TB without developing active disease, suggesting the presence of natural protective immunity. By characterising these immune signatures, his research aims to contribute to the development of improved TB vaccines and preventive strategies.

SANTHE is an Africa Health Research Institute (AHRI) flagship programme funded by the Science for Africa Foundation through the DELTAS Africa programme; the Gates Foundation; Gilead Sciences Inc.; and the Ragon Institute of Mass General, MIT, and Harvard.