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Mark Brockman

SANTHE Consortium Steering Committee Member


Simon Fraser University (SFU), Burnaby, Canada

Collaboration Interests
  • HIV latency and cure research
  • Immune receptor (TCR/BCR) profiling

Mark Brockman is a Professor in the Faculty of Health Sciences and the Department of Molecular Biology and Biochemistry. His research aims to understand the host and viral mechanisms that contribute to HIV pathogenesis and latency, including strategies used by HIV to evade the human immune response. Brockman received his PhD in Virology from Harvard University and conducted his post-doctoral training in Immunology at the Massachusetts General Hospital before joining the faculty at SFU in 2009. His ongoing research and training activities are supported by long-standing collaborations with researchers in Africa and the USA.

Publications
SARS-CoV-2 live virus neutralization after four COVID-19 vaccine doses in people with HIV receiving suppressive antiretroviral therapy Attenuated HIV-1 Nef But Not Vpu Function in a Cohort of Rwandan Long-Term Survivors HIV Proviral Burden, Genetic Diversity, and Dynamics in Viremic Controllers Who Subsequently Initiated Suppressive Antiretroviral Therapy Variation in HIV-1 Nef function within and among viral subtypes reveals genetically separable antagonism of SERINC3 and SERINC5 Differential Vpu-Mediated CD4 and Tetherin Downregulation Functions among Major HIV-1 Group M Subtypes Longitudinal within-host evolution of HIV Nef-mediated CD4, HLA and SERINC5 downregulation activity: a case study Natural HIV-1 Nef Polymorphisms Impair SERINC5 Downregulation Activity HIV Subtype and Nef-Mediated Immune Evasion Function Correlate with Viral Reservoir Size in Early-Treated Individuals Dual HLA B*42 and B*81-reactive T cell receptors recognize more diverse HIV-1 Gag escape variants

SANTHE is an Africa Health Research Institute (AHRI) flagship programme funded by the Science for Africa Foundation through the DELTAS Africa programme; the Bill & Melinda Gates Foundation; Gilead Sciences Inc.; and the Ragon Institute of Mass General, MIT, and Harvard.

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