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Projects

SANTHE-related projects focus on acute infection studies, HIV-1 vaccine research, TB research, HIV/TB co-infections, associated morbidities, and emerging diseases in Africa like SARS-CoV-2. SANTHE scientists are also encouraged to conduct community and public engagement (CPE) as well as diversity, equity and inclusion (DEI) projects to complement their research work.

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Collaborative 08 October 2023

Blood biomarkers that prospectively predict acute HIV-1 infection in high-risk adults

Africa bears the largest burden of HIV-1 transmission. It is not clear whether circulating virus characteristics, genetics, social-behavioural factors or exposure to other infections or some intrinsic biological mechanisms predisposes some individuals to HIV despite similar risk behaviour. In this…

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Collaborative 08 October 2023

Characterising currently circulating HIV in rural forest areas of Cameroon, where ancestors of HIV-1 have been identified

Despite the tremendous gains made towards ending HIV as a public health threat, the epidemic is still far from over. One of the main reasons is the diversity that the HIV group M (HIV-1M) virus exhibits. This affects both vaccine…

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C
Collaborative 08 October 2023

CTL specificities associated with spontaneous control of HIV clades A and C that are dominant in East and Southern Africa

It has become increasingly clear that the development of an effective HIV vaccine that prevents HIV transmission will likely require a coordinated T and B cell response. To design a T cell-based HIV vaccine that will be effective in sub-Saharan…

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Collaborative 12 March 2024

Antibody and T-Cell responses elicited by different SARS-CoV-2 vaccines in Botswana: durability and impact of HIV infection and previous SARS-CoV-2 and prevalent infection

The rapid spread of SARS-CoV-2 variants of concern (VOCs) that have accumulated mutations able to evade the complex immune system response generated by vaccination or prior infection has caused several distinct waves around the globe.  The rapid unprecedented development of…

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SANTHE is an Africa Health Research Institute (AHRI) flagship programme funded by the Science for Africa Foundation through the DELTAS Africa programme; the Bill & Melinda Gates Foundation; Gilead Sciences Inc.; and the Ragon Institute of Mass General, MIT, and Harvard.

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