Current MPhil Projects
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Comparison of an In-House Whole HIV-1 Pol Genotyping Assay to Viroseq for Detection of HIV-1 Drug Resistance Mutations in Patients Failing cART in Botswana
Mokaleng’s project looks at optimising the recently improved Long-Range HIV Genotyping for Analysis of HIV Drug Resistance and HIV Clustering in the Botswana population. In this project, they... Botswana Harvard AIDS Institute Partnership (BHP), Gaborone, Botswana
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Exploring the possible impact of HIV infection on the distribution of Human Papillomavirus virus (HPV) genotypes and host epigenetics changes associated with cervical cancer progression
With an intense, generalised HIV epidemic affecting all social strata and a strong programme to treat HIV and malignancies, Botswana provides a unique opportunity to address questions pertaining to... Botswana Harvard AIDS Institute Partnership (BHP), Gaborone, Botswana
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Genotypic characterisation of Mycobacterium tuberculosis strain isolates circulating in Botswana: an evaluation of strain patterns in relation to geographical distribution, HIV co-infection, TB re-infection and drug resistance
This will be the first study to report on the prevailing M. tuberculosis genotypes in Botswana and their association with HIV co-infection. This study also presents the first overview of M... Botswana Harvard AIDS Institute Partnership (BHP), Gaborone, Botswana
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Molecular characterisation of transmitted HIV- 1C from HIV infected mothers to their infants in Botswana
HIV-1 drug resistance genotyping has become a standard of care in HIV-1 infection management in developed countries but availability remains infrequent in the developing world. In Botswana, all HIV... Botswana Harvard AIDS Institute Partnership (BHP), Gaborone, Botswana
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Neutralisation of HIV-1 subtype C strains from recently infected individuals by broadly neutralising antibodies
HIV-1 neutralising and non-neutralising antibodies have been shown to play a role as correlates of protection from infection. It is important to determine the ability of these bnAbs to neutralise HIV... Botswana Harvard AIDS Institute Partnership (BHP), Gaborone, Botswana
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Pharmacogenetics of Efaverinz and Nevirapine and possible associated risk of selecting for HIV drug resistance mutations in Botswana.
The aim of Maseng’s project is to look at human genetic variation at the gene (Cytochrome P2B6) level as a possible host co-factor in selecting for non-nucleoside reverse transcriptase inhibitors (... Monkgomotsi Josephine Manewe Maseng
Botswana Harvard AIDS Institute Partnership (BHP), Gaborone, Botswana
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Prevalence of Minor HIV-1 Drug Resistant variants in Antiretroviral –naïve HIV-1 Infected Patients in Botswana
This project investigates the Prevalence of HIV-1 minor drug resistance variants in antiretroviral naive individuals in Botswana. Maruapula uses one of the cheaper, more sensitive assays, PAN... Botswana Harvard AIDS Institute Partnership (BHP), Gaborone, Botswana
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Prevalence of oncogenic Human Papillomavirus genotypes in patients diagnosed with anogenital malignancies in Botswana
Rantshabeng's study focuses on the high-risk Human papillomavirus (HPV) types that are associated with vulvar, penile, anal and cervical squamous cell carcinoma. Human papillomavirus (HPV) associated...