Exploring the possible impact of HIV infection on the distribution of Human Papillomavirus virus (HPV) genotypes and host epigenetics changes associated with cervical cancer progression

Exploring the possible impact of HIV infection on the distribution of Human Papillomavirus virus (HPV) genotypes and host epigenetics changes associated with cervical cancer progression

Associated Students: 
Email Address: 
tawel@bup.org.bw
Phone Number: 
+267 7 653-6906

With an intense, generalised HIV epidemic affecting all social strata and a strong programme to treat HIV and malignancies, Botswana provides a unique opportunity to address questions pertaining to cervical cancer and also to explore the epigenetic changes (DNA methylation profile of host genes) associated with possible linkages between HIV/HPV, and cervical cancer. Therefore, Tawe’s interest is to explore the possible impact of HIV infection on the distribution of Human Papillomavirus virus (HPV) genotypes and host epigenetics changes associated with cervical cancer progression.  Furthermore, he would also like to determine the HPV subtypes viral load in cervical tissues of women referred to colposcopy to determine HPV 16 and 18 viral load per million of human cells using cloned plasmids constructs for HPV-16 and -18 as standards for quantification.