The KAVI Institute of Clinical Research (KAVI-ICR) is a word-class research hub at the College of Health Sciences, University of Nairobi, spearheading research and training in global health. KAVI-ICR has conducted basic HIV, epidemiology research and eight HIV vaccine trials, 10 basic science, and epidemiological research studies. KAVI-ICR programmes are geared to understanding the underlying determinants of good health for prevention of both communicable and non-communicable diseases. Linking various health determinants to establish the best interventions and preventive measures is a key outcome from global health research. KAVI-ICR focuses on four themes coupled with attractive career paths that attract the best talent in Africa and serve the best interests of the general population. The Non-Communicable Diseases track includes cancers such as breast, colon, prostate cancers, as well as the diseases of the cardiovascular, respiratory, and endocrine systems. The Communicable Disease track focuses on HIV/AIDS, along with research on tuberculosis, zoonoses, and childhood respiratory and gastrointestinal diseases. The Clinical Trials track runs HIV vaccine trials in addition to trials for other products including chemotherapy drug trials. Finally, the Knowledge Translation track brings research, policy, and implementation together by building relationships and opportunities for collaboration between researchers and those who benefit from and use the research results.