Jesus Salazar is a senior molecular virologist and project leader at the MRC/UVRI Uganda Research Unit on AIDS. His research interests include the molecular mechanisms underlying the bottleneck in HIV-1 mucosal transmission and the nature of the transmitted virus. His studies are aimed at understanding how HIV-1 can remain successful despite its extraordinary diversity and high mutational rate, as this information may provide important clues to uncovering signatures that determine infectivity, virulence and heritability. Targeting virologic factors that are essential and evolutionarily conserved by vaccines and other therapeutic approaches should blunt or have a profound effect on virus replication and pathogenicity. Addessing these questions in Uganda and other sub-Saharan countries, where different HIV-1 subtypes co-circulate amid an increasing number of complex intersubtype recombinants, is one of the utmost challenges for developing a scientific rational for interventions. His laboratory focuses on the genotypic and phenotypic characterisation of the most common transmitted and circulating viruses in high-risk human populations from Uganda.