Projects

It has become increasingly clear that the development of an effective HIV vaccine that prevents HIV transmission will likely require a coordinated T and B cell response. To design a T cell-based HIV vaccine that will be effective in sub-Saharan…

Louis Kamulegeya’s study aims to assess how the micronutrient status among HIV-positive tuberculosis (TB) patients correlates with the severity of symptoms, diagnostic outcome and response to TB treatment at a public health facility in Uganda.  His research hopes to draw…

B cells form aggregates in the human lung following Mycobacterium tuberculosis (Mtb) infection. This phenomenon is also prevalent in animals including mice and non-human primates. Female mice have both larger and more numerous aggregates in their lungs and our preliminary…

In 2021, the United Nations Children’s Fund (UNICEF) reported 2.7 million children and adolescents living with HIV globally, with 88% living in Sub-Saharan Africa. Since the advent of universal anti-retroviral therapy (ART), the number of children dying from HIV worldwide…

HIV-1 subtypes have uneven prevalence and spread world-wide.  There is evidence tosuggest that there are differences in disease progression and transmissibility betweensubtypes that may underlie the uneven prevalence and spread.  The biological mechanismsthat favour the success of one subtype over…

Unidentified HIV infections are responsible for the continued transmission and sustenance of the HIV pandemic. Identifying populations at increased risk of HIV but who have low uptake of HIV testing is critical for the control and elimination of HIV. Adolescent…

Chivaura-Mudukuti’s research project will focus on evaluating antibody responses in three cohorts. These cohorts include anti-retroviral therapy (ART) naive HIV infected long term non-progressors and patients with advanced disease to evaluate antibodies in each cohort. It will also include a…

Pharmacogenetics is a field of science that is rapidly gaining interest in the world of medicine. It utilises a person’s genome (or genetic makeup), to identify drugs and/or drug doses that are likely to work best for that person, or…

The rapid spread of SARS-CoV-2 variants of concern (VOCs) that have accumulated mutations able to evade the complex immune system response generated by vaccination or prior infection has caused several distinct waves around the globe.  The rapid unprecedented development of…

Finding a cure for HIV means finding the reservoirs where HIV hides in the human body. Latent reservoirs for HIV can be found in multiple body compartments for example, the lymphoid tissues and brain, as well as in immune cell…