SANTHE-related projects focus on acute infection studies, HIV-1 vaccine research, TB research, HIV/TB co-infections, associated morbidities, and emerging diseases in Africa like SARS-CoV-2. SANTHE scientists are also encouraged to conduct community and public engagement (CPE) as well as diversity, equity and inclusion (DEI) projects to complement their research work.


Signature of long-lived HIV-specific memory B-cell lineages

Daniel Muema’s work will contribute to informing how HIV vaccines can be designed to confer long-lasting protection from HIV infection. So far, a licensed effective HIV vaccine does not exist. There are, however, several candidate HIV vaccines in early stages…

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Understanding CD8+ T cell-mediated HIV control (subtypes A and C) in eastern and southern Africa: emphasis on dominant networked epitopes and HLA class I alleles

The development of an effective HIV vaccine has been hindered mainly due to the ability of the virus to evolve and escape the host’s defence system. However, the discovery and analysis of highly networked epitopes (regions/parts) of the virus has…

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Genetic diversity of HIV-1 CRF02_AG envelop gene among individuals with chronic infection in Cameroon: implication for vaccine development

Despite more than three decades of research, a protective vaccine against HIV-1 group M (HIV-1M) remains elusive. To date, none of the vaccine candidates tested has been able to induce effective humoral immunity. Nevertheless, neutralising antibodies (nAbs) in the broad…

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Molecular epidemiology of HIV-1 non-M variants and HIV-1 M+O dual infections among HIV positive patients in Cameroon

Aurélie Kifack Zetang’s project focusses on the molecular epidemiology of non-M HIV-1 variants and dual M+O HIV-1 infections in HIV-positive patients in Cameroon. HIV-1 is very diverse and this high genetic diversity has an impact on the diagnosis, treatment and…

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Deciphering the impact of sex on immune cell activation, nature of the HIV reservoir and reactivation in the presence or absence of sex hormones in ART-suppressed people living with HIV

Despite the success of antiretroviral therapy (ART) in managing clinical disease and preventing viral transmission, there is still no vaccine or cure for HIV. The persistence of virus-infected human cells that remain dormant during ART, poses a significant barrier to…

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Characterising immune signatures in recent asymptomatic Mycobacteria (Mtb) infection to reveal correlates of protection in Mtb infection and TB disease

Maseema and his team aim to uncover immune correlates of protection in subclinical Mycobacterial tuberculosis (Mtb) infection and TB disease. The majority of individuals who are exposed to Mtb infection successfully contain the infection whereby only an immunological memory remains…

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Accessibility of point-of-care diagnostics for prevention of vertical disease transmission in rural primary health care clinics in Zambia

The main objective of Katoba’s study is to explore barriers and challenges related to the accessibility of point-of-care (POC) diagnostics for prevention of vertically transmitted infections in rural primary health care clinic (PHCs) settings of Zambia. The specific aims are:…

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HIV-1 Genetic Diversity and Drug Resistance Mutations among Pregnant Women and Breastfeeding Mothers in Uganda

Uganda still falls short of the World Health Organisation’s targets of viral load suppression among the breastfeeding and pregnant women. This may be explained by increased levels of HIV-1 drug resistance mutations (HIV-DRMs) subsequently increasing the risk of vertical transmission…

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SANTHE is an Africa Health Research Institute (AHRI) flagship programme funded by the Science for Africa Foundation through the DELTAS Africa programme; the Bill & Melinda Gates Foundation; Gilead Sciences Inc.; and the Ragon Institute of Mass General, MIT, and Harvard.