Generation and characterisation of infectious molecular clones of transmitted/founder HIV-1 subtype C viruses

Generation and characterisation of infectious molecular clones of transmitted/founder HIV-1 subtype C viruses

Associated Students: 
Project Level: 
Email Address: 
bonisile.luthuli@ahri.org
Phone Number: 
+27 (0) 31 260 4174

In most heterosexual transmission, HIV infection is usually established by one or a few viruses while the infected partner has many viruses. Luthuli will be studying the characteristics of the transmitted viruses known as the transmitted/founder virus. Her aim is to determine the features of the transmitted viruses that are associated with successful transmission and productive establishment of HIV infection. Understanding these characteristics of the transmitted viruses will assist in preventing HIV infections.